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A Health-Related Quality of Life Measure in Patients with Deep Vein Thrombosis: A Validation Study

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Abstract

This study was conducted to test the psychometric properties of a newly developed health-related quality of life (HRQOL) questionnaire. One hundred eleven individuals identified through a registry and medical records who experienced an acute iliofemoral deep vein thrombosis (DVT) more than six months ago completed the questionnaire (containing the Health Utilities Index and Short Form-12, and DVT-specific scales). Respondents were primarily female, Caucasian, and married with an average age of 54 years. Internal-consistency reliability was acceptable (Cronbach’s alpha: 0.69–0.95). Interscale correlations were as expected. In general, patients with no symptoms reported the highest functioning, those with severe symptoms the lowest, and those with moderate symptoms reported values between the two. Guyatt’s statistic values for the majority of scales were ≥|0.20|, demonstrating acceptable responsiveness to change. Psychometric testing indicated that the measure is reliable, valid, and responsive in this group. Future research will focus on further evaluating its use in studies of patients receiving different therapies for acute DVT.

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References

  1. O’Donnell TF, Jr., Browse NL, Burnand KG, Thomas M. The socioeconomic effects of an iliofemoral venous thrombosis. J Surg Res. 1977;22(5):483–488.

    Article  Google Scholar 

  2. Beyth RJ, Cohen AM, Landefeld CS. Long-term outcomes of deep-vein thrombosis. Arch Intern Med. 1995;155(10):1031–1037.

    Article  Google Scholar 

  3. Creager MA, Dzau VJ. Deep venous thrombosis. In: Fauci AS, Braunwald E, Isselbacher KJ, et al. eds. Harrison’s Principles of Internal Medicine. 14th Edition. McGraw Hill: New York; 1998:1398–1406.

    Google Scholar 

  4. Anderson FA, Jr., Wheeler HB, Goldberg RJ, Hosmer DW, Patwardhan NA, Jovanovic B, et al. A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study. Arch Intern Med. 1991;151:933–938.

    Article  Google Scholar 

  5. King MS. Preventing deep venous thrombosis in hospitalized patients. Am Fam Physician. 1994; 49(6):1389–1396.

    CAS  PubMed  Google Scholar 

  6. Bell WR, Simon TL. Current status of pulmonary thromboembolic disease: pathophysiology, diagnosis, prevention, and treatment. Am Heart J. 1982;103:239–262.

    Article  CAS  Google Scholar 

  7. Browse NL, Clemenson G, Lea TM. Is the postphle-bitic leg always postphlebitic? Relation between phlebographic appearances of deep-vein thrombosis and late sequelae. Br Med J. 1980;281:1167–1170.

    Article  CAS  Google Scholar 

  8. Tierney LM, McPhee SJ, Papadakis MA, eds. Current Medical Diagnosis & Treatment. 34th Edition. Paramus, NJ: Prentice-Hall International, Inc.; 1995.

    Google Scholar 

  9. Menzin J, Colditz GA, Regan MM, Richner RE, Oster G. Cost-effectiveness of enoxaparin vs. low-dose warfarin in the prevention of deep-vein thrombosis after total hip replacement surgery. Arch Intern Med. 1992; 152:165–175.

    Article  Google Scholar 

  10. Hull RD, Feldstein W, Pineo GF, Raskob GE. Cost-effectiveness of diagnosis of deep vein thrombosis in symptomatic patients. Thromb Haemost. 1995;74(1):189–196.

    Google Scholar 

  11. Drummond M, Aristides M, Davies L, Forbes C. Economic evaluation of standard heparin and enoxaparin for prophylaxis against deep vein thrombosis in elective hip surgery. Br J Surg. 1994;81:1742–1746.

    Article  CAS  Google Scholar 

  12. Launois R, Reboul-Marty J, Henry B. Construction and validation of a quality of life questionnaire in chronic lower limb venous insufficiency (CIVIQ). Qual Life Res. 1996;5(6):539–554.

    Article  Google Scholar 

  13. Feeny DH, Torrance GW, Furlong WJ. Health Utilities Index. In: Spilker B, Ed. Quality of Life and Pharmacoeconomics in Clinical Trials. 2nd edition. Philadelphia: Lippincott-Raven Publishers; 1996:239–252.

    Google Scholar 

  14. Torrance GW, Feeny DH, Furlong WJ, Barr RD, Zhang Y, Wang Q. Multi-attribute preference functions for a comprehensive health status classification system: Health Utilities Index HUI 2. Med Care. 1996;24(7):702–722.

    Article  Google Scholar 

  15. Ware JE, Jr., Kosinski M, Keller SD. SF-12: How to Score the SF-12 Physical and Mental Health Summary Scales. 2nd Edition. Boston, MA: The Health Institute, New England Medical Center; 1995.

    Google Scholar 

  16. Stewart AL, Ware JE, Jr., eds. Measuring Functioning and Well-Being. The Medical Outcomes Study Approach. Durham, NC: Duke University Press; 1992.

    Book  Google Scholar 

  17. Ware JE, Jr., Snow KK, Kosinski M, Gandek B. SF-36 Health Survey. Manual and Interpretation Guide. Boston, MA: The Health Institute, New England Medical Center; 1993.

    Google Scholar 

  18. Cronbach LJ. Coefficient alpha and the internal structure of tests. Psychometrika. 1951;16:297.

    Article  Google Scholar 

  19. Rosner B. Fundamentals of Biostatistics. Belmont, CA: Duxbury Press, 1995:519.

  20. Arnesen H, Hoiseth A, Ly B. Streptokinase or heparin in the treatment of deep vein thrombosis. Follow-up results of a prospective study. Acta Med Scand. 1982;211:65–68.

    CAS  PubMed  Google Scholar 

  21. Deyo RA, Diehr P, Patrick DL. Reproducibility and responsiveness of health status measures. Statistics and strategies for evaluation. Control Clin Trials. 1991;12:142S–158S.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Lewin-TAG, Inc., 490 Second Street, Suite 201, San Francisco, California, 94107, USA

    Susan D. Mathias MPH (Senior Director, Quality of Life Research) & Lee Ann Prebil (Associate)

  2. Abbott Laboratories, Abbot Park, Illinois, USA

    Caryn G. Putterman (Manager, Health Outcomes Research) & Joseph J. Chmiel PhD (Director of Epidemiologic Statistics)

  3. School of Medicine, Temple University, Philadelphia, Pennsylvania, USA

    Richard C. Throm (Clinical Research Coordinator) & Anthony J. Comerota MD, FACS (Professor Surgery and Chief of Vascular Surgery)

Authors
  1. Susan D. Mathias MPH
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  2. Lee Ann Prebil
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  3. Caryn G. Putterman
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  4. Joseph J. Chmiel PhD
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  5. Richard C. Throm
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  6. Anthony J. Comerota MD, FACS
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Corresponding author

Correspondence to Susan D. Mathias MPH.

Additional information

This study was supported by Abbott Laboratories.

Preliminary results of this study were presented at the DIA Fifth Annual “Symposium of Contributed Papers on Quality of Life Evaluation,” April 6–7, 1998, Hilton Head, South Carolina.

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Mathias, S.D., Prebil, L.A., Putterman, C.G. et al. A Health-Related Quality of Life Measure in Patients with Deep Vein Thrombosis: A Validation Study. Ther Innov Regul Sci 33, 1173–1187 (1999). https://doi.org/10.1177/009286159903300421

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  • DOI: https://doi.org/10.1177/009286159903300421

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